Sodium Hydroxide → Octimibate

HRID 1462454노트

반응식

HRID 1462454 반응식
C[O:2][C:3](=[O:35])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]1[N:13]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:14]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:16]=1.[OH-].[Na+]>CO.O>[C:29]1([N:13]2[C:14]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[C:15]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:16]=[C:12]2[O:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:35])=[O:2])[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 13279625Methyl 8-[(1,4,5-triphenyl-1H-imidazol-2-yl)oxy]octanoate

생성물 1

HCID 65676Octimibate

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

171 g of methyl-8-(1,4,5-triphenylimidazol-2-yloxy)-caprylate and 44 g of sodium hydroxide are dissolved in 1,000 ml of methanol and the mixture is stirred at room temperature for about 24 hours. The solvent is then stripped off in vacuo and the residue is taken up in water. The aqueous solution is washed with ether and acidified with dilute hydrochloric acid and the acid precipitated is separated off and dried.

후처리

  1. washThe aqueous solution is washed with ether
  2. customthe acid precipitated
  3. customis separated off
  4. customdried

출처 및 근거

ORD 기록
ord-cbae23275b5641c1919af98ca6bb983a
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04460598

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