Phenol → 3-[1-(4-Hydroxyphenyl)-isopropyl]phenol

HRID 1462659

반응식

HRID 1462659 반응식
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)[OH:9].O[C:14]1[CH:15]=[C:16]([C:20]([CH3:23])([CH3:22])O)[CH:17]=[CH:18][CH:19]=1>C1(C)C=CC=CC=1>[OH:7][C:1]1[CH:6]=[C:5]([C:20]([C:16]2[CH:17]=[CH:18][C:19]([OH:9])=[CH:14][CH:15]=2)([CH3:23])[CH3:22])[CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 996Phenol2회HCID 1118Sulfuric AcidHCID 4581423-(2-Hydroxypropan-2-yl)phenol

생성물 1

HCID 6882893-[1-(4-Hydroxyphenyl)-isopropyl]phenol수율 55%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

A mixture of 1335 grams (14.2 moles) of phenol, 450 ml. of 75% aqueous sulfuric acid and 1800 ml. of toluene was stirred at room temperature while a solution of 450 grams (2.9 moles) of 3-hydroxyphenyldimethylcarbinol in 890 grams (9.5 moles) of phenol and 1800 ml. of toluene was added over three hours. The reaction mixture was stirred at room temperature for four hours and the aqueous layer was separated and discarded. The organic layer was washed twice with water, once with 10% sodium bicarbonate solution and again with water. Toluene and excess phenol were removed by vacuum distillation and the residue was recrystallized from toluene. There was obtained 371 grams (55% of theoretical) of the desired 2-(3-hydroxyphenyl)-2-(4-hydroxyphenyl)propane.

후처리

  1. customthe aqueous layer was separated
  2. washThe organic layer was washed twice with water, once with 10% sodium bicarbonate solution and again with water
  3. customToluene and excess phenol were removed by vacuum distillation
  4. customthe residue was recrystallized from toluene

출처 및 근거

ORD 기록
ord-554cd87da3cd43c08592993d77fc3552
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04460798

연결된 노트

불러오는 중…