Phosphoric Acid → HCID 2802466, 화합물

HRID 1462947

반응식

HRID 1462947 반응식
[OH:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[C:4](=[O:14])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1.P(=O)(O)(O)O>COCCO.O>[CH3:13][C:10]1[CH:11]=[CH:12][C:7]([CH:6]2[CH2:5][C:4](=[O:14])[C:3]3[C:2](=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:1]2)=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 1004Phosphoric AcidHCID 6172491-(2-Hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one

생성물 1

HCID 2802466HCID 2802466, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 80192-Methoxyethanol용매

실험 절차

The 2'-Hydroxy-4-methylchalcone of Example 13 (7.3 g.) was boiled under reflux with a solution of 85% phosphoric acid (22 ml.) in 2-methoxyethanol (219 ml.) for 8 hrs. The reaction mixture was diluted with water (1 liter) and the oily precipitate extracted into dichloromethane (300 ml.). The organic extract was separated and washed with water and saturated sodium bicarbonate solution. Filtration and evaporation gave a residue of 4'-methylflavanone contaminated with the starting chalcone.

후처리

  1. extractionthe oily precipitate extracted into dichloromethane (300 ml.)
  2. extractionThe organic extract
  3. customwas separated
  4. washwashed with water and saturated sodium bicarbonate solution
  5. filtrationFiltration and evaporation

출처 및 근거

ORD 기록
ord-384e663e01314cf0b77e10d0f218e8a6
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04461907

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