Formaldehyde → 3,5-Dichlorosalicyl alcohol
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[OH:9].[OH-:10].[Na+].[CH2:12]=O>S(=O)(=O)(O)O>[Cl:1][C:2]1[C:3]([OH:9])=[C:4]([CH:5]=[C:6]([Cl:8])[CH:7]=1)[CH2:12][OH:10]참가 물질
5
실험 절차
A mixture of 2,4-dichlorophenol (15.3 g), 10% sodium hydroxide solution (100 ml) and 40% aqueous formaldehyde solution (37.5 ml) was heated at 95°-100° C. for 4 hr, then cooled and acidified by addition of 2-normal sulphuric acid (70 ml). The precipitated oil was extracted into toluene, and the extract washed with sodium bicarbonate solution, dried and evaporated. The residue was recrystallised from boiling water to yield 3,5-dichloro-2-hydroxybenzyl alcohol (4.0 g), m.p. 81°-82° C. on drying at 56° C./20 mm. Hg=2660 Pa.
후처리
- temperaturewas heated at 95°-100° C. for 4 hr
- temperaturecooled
- extractionThe precipitated oil was extracted into toluene
- washthe extract washed with sodium bicarbonate solution
- customdried
- customevaporated
- customThe residue was recrystallised
출처 및 근거
- ORD 기록
- ord-3ada45b6e1414c3daf08adc4c2c5dc3f
- 출처 데이터셋
- uspto-grants-1984_07
- 특허 번호
- US04461907
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