Hydrogen Bromide → hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one

HRID 1463113노트

반응식

HRID 1463113 반응식
Cl[C:2]1[C:7](=[O:8])[CH2:6][CH2:5][CH2:4][C:3]=1[CH:9]1[CH2:15][CH2:14][CH2:13][CH2:12][N:11]([CH3:16])[C:10]1=[O:17].Br.O>C(O)(=O)C>[OH:8][C:7]1[CH:2]=[C:3]([CH:9]2[CH2:15][CH2:14][CH2:13][CH2:12][N:11]([CH3:16])[C:10]2=[O:17])[CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 962WaterHCID 28175763-(2-Chloro-3-oxocyclohex-1-enyl)-hexahydro-1-methylazepin-2-one

생성물 1

HCID 11746121hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one

시약·촉매·용매 1

HCID 176Acetic Acid용매3회

실험 절차

Using acetic acid as solvent. A solution of 3-(2-chloro-3-oxocyclohex-1-enyl)-hexahydro-1-methylazepin-2-one (5.12 g) in glacial acetic acid (50 ml) was treated with 48% HBr in acetic acid (2 ml). After 12 hours the reaction mixture was poured on to water and the resulting precipitate removed by filtration to yield the title compound m.p. 192°-3° C. (EtOAc).

후처리

  1. customthe resulting precipitate removed by filtration

출처 및 근거

ORD 기록
ord-4a5f25e5f58f4655ad01fc46ba1b8ba9
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04463177

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