2-(2-Bromophenoxymethyl)benzoic acid → 4-Bromo-6,11-dihydrodibenz[b,e]oxepin-11-one
반응식
[Br:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][CH2:5][C:6]1[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=O>FC(F)(F)C(OC(=O)C(F)(F)F)=O>[Br:1][C:2]1[C:3]2[O:4][CH2:5][C:6]3[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=3[C:8](=[O:10])[C:15]=2[CH:16]=[CH:17][CH:18]=1참가 물질
3
실험 절차
A suspension of 2-(2-bromophenoxymethyl)benzoic acid (18.8 g, 0.06 mole) in 100 mL of trifluoracetic anhydride containing ten drops of boron trifluoride-ether complex was refluxed for four hours. The mixture was poured into ice water and then extracted with diethyl ether. Concentration of the ether solution under reduced pressure gave the pure product (9.2 g), mp 127°-130° C. pmr (CDCl3) δ: 7.28-8.19 (m, 76H, aromatic H); 6.99 (t, 1H, H2); 5.30 (s, 2H, ArCH2O).
후처리
- temperaturewas refluxed for four hours