Sodium borohydride → 2,3,4,5-Tetrahydro-alpha-methyl-1-benzoxepine-7-methanol

HRID 1463395노트

반응식

HRID 1463395 반응식
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][C:7]2[O:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[CH:14]=1)=[O:3].[BH4-].[Na+]>CO>[CH3:1][CH:2]([C:4]1[CH:5]=[CH:6][C:7]2[O:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[CH:14]=1)[OH:3]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 133015981-(2,3,4,5-Tetrahydrobenzo[b]oxepin-7-yl)ethanone

생성물 1

HCID 199353892,3,4,5-Tetrahydro-alpha-methyl-1-benzoxepine-7-methanol수율 81.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

6.90 g of 2,3,4,5-tetrahydro-1-benzoxepin-7-yl methyl ketone in 60 ml of methanol were treated portionwise with 2.33 g of sodium borohydride (NaBH4) at 0° C. while stirring. After a half hour the reaction mixture was poured on to ice, extracted with ether. The extract was washed with water, dried and evaporated. Chromatography on silica gel (petroleum ether/ethyl acetate 8:2) yielded 5.71 g of 2,3,4,5-tetrahydro-α-methyl-1-benzoxepine-7-methanol as a colorless oil.

후처리

  1. additionAfter a half hour the reaction mixture was poured on to ice
  2. extractionextracted with ether
  3. washThe extract was washed with water
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-520d6a9b2c5d4067879ce702f29d5b6e
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05300522

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