Diethyl 3-trifluoromethylbenzylphosphonate → ((3-Trifluoromethyl)phenyl)methyl-phosphonic acid
반응식
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[CH2:6][P:7](=[O:14])([O:11]CC)[O:8]CC>Cl.CCO>[F:18][C:2]([F:1])([F:19])[C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[CH2:6][P:7](=[O:8])([OH:11])[OH:14]참가 물질
4
실험 절차
Diethyl 3-trifluoromethylbenzylphosphonate (3.0 g, 10.0 mmol) was dissolved in a mixture of 50 mL of conc hydrochloric acid and 1.5 mL of EtOH and was heated at reflux for 17 hours. After cooling the clear reaction mixture in an ice-water mixture, the white crystalline solid which formed was collected to give 2.05 g (84.3%) of the analytical product, mp=163°-164° C.; D.C.I.M.S.[MH+,241].
후처리
- temperaturewas heated
- temperatureat reflux for 17 hours
- customthe white crystalline solid which formed
- customwas collected
출처 및 근거
- ORD 기록
- ord-bd957050fe8c4a5e8f4561d45493a7c1
- 출처 데이터셋
- uspto-grants-1994_04
- 특허 번호
- US05300687
반응 노트
불러오는 중…