Diethyl {[3,5-bis(trifluoromethyl)phenyl]methyl}phosphonate → HCID 15818098, 화합물
반응식
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1)[CH2:6][P:7](=[O:14])([O:11]CC)[O:8]CC>Cl.C(O)C>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[C:5]([CH:15]=[C:16]([C:18]([F:21])([F:19])[F:20])[CH:17]=1)[CH2:6][P:7](=[O:8])([OH:11])[OH:14]참가 물질
4
실험 절차
Diethyl 3,5-bis(trifluoromethyl)benzylphosphonate (1.0 g, 2.7 mmol) in 15 mL of conc hydrochloric acid and 0.5 mL of ethanol was heated at reflux for 72 hours. The mixture was evaporated to an oily residue which crystallized upon standing to give 0.41 g of the product (49% yield) the as a white solid: mp. 206°-208° C.; D.C.I.M.S. [MH+, 309].
후처리
- temperatureat reflux for 72 hours
- customThe mixture was evaporated to an oily residue which
- customcrystallized
출처 및 근거
- ORD 기록
- ord-ac9cd42d81d24031ba0d1272d16a818e
- 출처 데이터셋
- uspto-grants-1994_04
- 특허 번호
- US05300687
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