Isopropyl 3-aminopropyl(ethyl)phosphinate → Cgp-36216

반응식

[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH2:11][CH3:12])(=[O:10])[O:6]C(C)C>Cl>[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH2:11][CH3:12])(=[O:6])[OH:10]

참가 물질

실험 절차

A mixture of 7.73 g of isopropyl 3-aminopropyl(ethyl)-phosphinate and 40 ml of 20% hydrochloric acid is refluxed with stirring for 14 hours. The clear solution is evaporated to dryness and the residue is recrystallized from methanol/propylenoxide to give 3-aminopropyl(ethyl)phosphinic acid as a white solid, m.p. 233°-239°; 1H-NMR (D2O): 0.4-1.8 (m, 9H, PCH2CH2 and PCH2CH3); 2.7 (t, 2H, NCH2); 4.55 (s, 3H, OH, NH2).

후처리

temperatureis refluxed
customThe clear solution is evaporated to dryness
customthe residue is recrystallized from methanol/propylenoxide

출처 및 근거

ORD 기록: ord-a2493e04b7e14229a9816dfe5013b4cb
출처 데이터셋: uspto-grants-1994_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05300679

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참가 물질

반응물 1

HCID 19090904Isopropyl 3-aminopropyl(ethyl)phosphinate

생성물 1

HCID 9898878Cgp-36216

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

후처리

temperatureis refluxed
customThe clear solution is evaporated to dryness
customthe residue is recrystallized from methanol/propylenoxide

출처 및 근거

ORD 기록: ord-a2493e04b7e14229a9816dfe5013b4cb
출처 데이터셋: uspto-grants-1994_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05300679

반응 노트

불러오는 중…