1-Propanol → 2-Propoxythiophene

HRID 1464126노트

반응식

HRID 1464126 반응식
I[C:2]1[S:3][CH:4]=[CH:5][CH:6]=1.[Na].[CH2:8]([OH:11])[CH2:9][CH3:10]>>[CH2:8]([O:11][C:2]1[S:3][CH:4]=[CH:5][CH:6]=1)[CH2:9][CH3:10]

참가 물질

4

반응물 3

HCID 10311-PropanolHCID 189212-IodothiopheneHCID 5360545Sodium

생성물 1

HCID 190893322-Propoxythiophene수율 13.5%

실험 절차

Iodothiophene (59 g, 281 mmole) and cupric oxide (11.2 g, 141 mmole) were placed in propanol (420 g) containing sodium (19.7 g, 857 mmole). The mixture was stirred at reflux for 48 hours and then filtered. The filtrate was added to cold water and the water extracted with ethyl ether. The ether layers were combined, dried over magnesium sulfate, filtered, concentrated, and then vacuum distilled from over sodium at 50° C. and 10 torr to provide 5.4 g of product.

후처리

  1. temperatureat reflux for 48 hours
  2. filtrationfiltered
  3. additionThe filtrate was added to cold water
  4. extractionthe water extracted with ethyl ether
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated
  8. distillationvacuum distilled from over sodium at 50° C.

출처 및 근거

ORD 기록
ord-2a2513057be045588a9e1994a95d9d47
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05302724

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