3-Oxobutyronitrile → 2-(2-Chloro-5-pyridylmethylamino)-1-cyano-1-propene

HRID 1464266

반응식

HRID 1464266 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][N:3]=1.[C:10]([CH2:12][C:13](=O)[CH3:14])#[N:11]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:13]([CH3:14])=[CH:12][C:10]#[N:11])=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 755793-OxobutyronitrileHCID 70209275-(Aminomethyl)-2-chloropyridine

생성물 1

HCID 867477702-(2-Chloro-5-pyridylmethylamino)-1-cyano-1-propene수율 85%

실험 절차

1.4 g of 2-chloro-5-pyridylmethylamine and 0.8 g of 1-cyano-2-propanone were mixed and the mixture was stirred at room temperature over night. The solvent was then distilled off and the residue was purified by column chromatography on silica gel to afford 1.7 g of compound No. 528. m.p. 95°-98° C.

후처리

  1. distillationThe solvent was then distilled off
  2. customthe residue was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-0787945b338f4211b0c021907cfd5215
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05304566

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