Acetic Anhydride → 2-acetoxymethyl-5-methoxy-N-(3-pyridylmethyl)benzamide

HRID 1464299

반응식

HRID 1464299 반응식
[OH:1][CH2:2][C:3]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:4]=1[C:5]([NH:7][CH2:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[O:6].C(N(CC)CC)C.[C:28](OC(=O)C)(=[O:30])[CH3:29]>C(Cl)Cl>[C:28]([O:1][CH2:2][C:3]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:4]=1[C:5]([NH:7][CH2:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[O:6])(=[O:30])[CH3:29]

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 200820052-hydroxymethyl-5-methoxy-N-(3-pyridylmethyl)benzamide

생성물 1

HCID 200820032-acetoxymethyl-5-methoxy-N-(3-pyridylmethyl)benzamide수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 710 mg of 2-hydroxymethyl-5-methoxy-N-(3-pyridylmethyl) benzamide and 317 mg of triethylamine in 10 ml of methylene chloride was chilled at 0° C., mixed with 320 mg of acetic anhydride and stirred at room temperature for 15 hours. The reaction mixture was washed with water and saturated brine in order. The organic layer was dried over anhydrous magnesium sulfate and concentrated in vacuo to give 820 mg of the titled compound.

후처리

  1. washThe reaction mixture was washed with water and saturated brine in order
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-417f44e2e8774e5bb426b3d89b2514ab
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05304556

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