Hydrochloric Acid → (3S,4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(1R)-1-[(methylthio)thiocarbonyl}ethyl]-2-oxoazetidine

HRID 1464722

반응식

HRID 1464722 반응식
C(N(CC)CC)C.[C:8]([S:12][CH3:13])(=[S:11])[CH2:9][CH3:10].C(O[C@H:18]1[NH:21][C:20](=[O:22])[C@@H:19]1[C@H:23]([O:25][Si:26]([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:28])[CH3:27])[CH3:24])(=O)C.Cl>C(#N)C.[Cl-].[Zn+2].[Cl-].ClCCl>[Si:26]([O:25][C@@H:23]([C@@H:19]1[C@@H:18]([C@H:9]([C:8]([S:12][CH3:13])=[S:11])[CH3:10])[NH:21][C:20]1=[O:22])[CH3:24])([C:29]([CH3:30])([CH3:31])[CH3:32])([CH3:27])[CH3:28]

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 223580Methyl propanedithioateHCID 10935078Azetidon

생성물 1

HCID 57309161(3S,4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(1R)-1-[(methylthio)thiocarbonyl}ethyl]-2-oxoazetidine수율 69.5%

시약·촉매·용매 3

HCID 3007855Zincchloride촉매HCID 6342Acetonitrile용매2회HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a suspension of anhydrous zinc chloride (45.3 g) in acetonitrile (450 ml) cooled to 0° C. was added triethylamine (101 g). After stirring for 30 minutes at 0° C., the solution was cooled to -35° C. and a mixture of methyl dithiopropionate (20.0 g) and (3R,4R)-4-acetoxy-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-oxoazetidine (23.9 g) in acetonitrile (90 ml) was added thereto. The reaction mixture was stirred at -20° C. for 2 hours, warmed to 0° C., and additionally stirred for 30 minutes at 0° C. The mixture was poured into a stirred mixture of dichloromethane (800 ml) and 1N hydrochloric acid (1000 ml). The organic layer was separated, washed with water, aqueous sodium bicarbonate solution and brine, and dried. The solution was concentrated under reduced pressure and the solid residue was washed with n-hexane to afford (3S,4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(1R)-1-{(methylthio)thiocarbonyl}ethyl]-2-oxoazetidine (20.1 g) as a yellow crystal.

후처리

  1. temperaturethe solution was cooled to -35° C.
  2. additionwas added
  3. stirringThe reaction mixture was stirred at -20° C. for 2 hours
  4. temperaturewarmed to 0° C.
  5. stirringadditionally stirred for 30 minutes at 0° C
  6. customThe organic layer was separated
  7. washwashed with water, aqueous sodium bicarbonate solution and brine
  8. customdried
  9. concentrationThe solution was concentrated under reduced pressure
  10. washthe solid residue was washed with n-hexane

출처 및 근거

ORD 기록
ord-8ebceed7fa414a45907d86cc7076cf97
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05306816

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