4-Ethylaniline → 2-Bromo-4-ethylaniline
반응식
[CH2:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1)[CH3:2].C1C(=O)N([Br:17])C(=O)C1>CN(C=O)C>[Br:17][C:5]1[CH:4]=[C:3]([CH2:1][CH3:2])[CH:9]=[CH:8][C:6]=1[NH2:7]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
To 4-ethylaniline (1.76 g, 14.52 mmol) and NBS (2.58 g, 14.52 mmol) was added DMF (67 mL) and the reaction mixture was stirred at 0° C. for 10 min. The reaction mixture was purified by silica gel chromatography (0-50% ethyl acetate/hexanes) to provide 2-bromo-4-ethylaniline (2.7 g, 93% yield). LC/MS m/z 201.0 [M+H]+.
후처리
- customThe reaction mixture was purified by silica gel chromatography (0-50% ethyl acetate/hexanes)
출처 및 근거
- ORD 기록
- ord-ceeabcfa63a949dfa1cd628243a74b3f
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US08999976B2
반응 노트
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