Bromine → HCID 86657727, 화합물

HRID 1465598노트

반응식

HRID 1465598 반응식
[CH3:1][C:2]1[C:7]([C:8](=[O:10])[CH3:9])=[C:6]([CH3:11])[CH:5]=[C:4]([CH3:12])[N:3]=1.[Br:13]Br>Br.C(O)(=O)C>[BrH:13].[Br:13][CH2:9][C:8]([C:7]1[C:2]([CH3:1])=[N:3][C:4]([CH3:12])=[CH:5][C:6]=1[CH3:11])=[O:10]

참가 물질

5

반응물 2

HCID 24408BromineHCID 2681241-(2,4,6-Trimethylpyridin-3-yl)ethan-1-one

생성물 1

HCID 86657727HCID 86657727, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매2회HCID 260Hydrogen Bromide용매

반응 조건

온도
70 °C

실험 절차

To a solution of 1-(2,4,6-trimethylpyridin-3-yl)ethanone (5.0 g, 30.6 mmol) in 33% HBr in acetic acid solution (10.2 mL) was added bromine (1.57 ml, 30.6 mmol) in acetic acid (10.2 mL) dropwisely. The reaction was stirred at 70° C. for 2.0 h. The solution was cooled to room temperature and washed with ether. The residue was dried under reduced pressure to give 2-bromo-1-(2,4,6-trimethylpyridin-3-yl)ethanone hydrobromide, which was used directly for the next step without further purification.

후처리

  1. temperatureThe solution was cooled to room temperature
  2. washwashed with ether
  3. customThe residue was dried under reduced pressure

출처 및 근거

ORD 기록
ord-9d6118915bef4fbf99a9b421e3fa4b44
출처 데이터셋
uspto-grants-2015_04
특허 번호
US08999983B2

반응 노트

불러오는 중…