1-(2-Chloro-4-fluoro-5-nitrophenyl)-3-methyl-s-triazine-2,4,6(1H,3H,5H)-trione → 1-(5-Amino-2-chloro-4-fluorophenyl)-3-methyl-s-triazine

HRID 1466

반응식

HRID 1466 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:9]([O-])=O)=[CH:4][C:3]=1[N:12]1[C:17](=O)[NH:16][C:15](=O)[N:14]([CH3:20])[C:13]1=O.[H][H]>[Pt].C(OCC)(=O)C>[NH2:9][C:5]1[C:6]([F:8])=[CH:7][C:2]([Cl:1])=[C:3]([N:12]2[CH:17]=[N:16][CH2:15][N:14]([CH3:20])[CH2:13]2)[CH:4]=1

참가 물질

5

반응물 2

HCID 572803321-(2-Chloro-4-fluoro-5-nitrophenyl)-3-methyl-s-triazine-2,4,6(1H,3H,5H)-trioneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 1317205461-(5-Amino-2-chloro-4-fluorophenyl)-3-methyl-s-triazine

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 1-(2-chloro-4-fluoro-5-nitrophenyl)-3-methyl-s-triazine-2,4,6(1H,3H,5H)-trione (28.5 g, 0.09 mol) and 5% platinum on activated carbon (1 g) in ethyl acetate is hydrogenated at 55 psi until hydrogen uptake is complete. The reaction mixture is then filtered and concentrated in vacuo to give the title product as a white solid, mp 244°-245° C.

후처리

  1. filtrationThe reaction mixture is then filtered
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-08b8b8866d334d3cae4bec9581c21467
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05726126

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