1-(2-Chloro-4-fluoro-5-nitrophenyl)-3-methyl-s-triazine-2,4,6(1H,3H,5H)-trione → 1-(5-Amino-2-chloro-4-fluorophenyl)-3-methyl-s-triazine
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:9]([O-])=O)=[CH:4][C:3]=1[N:12]1[C:17](=O)[NH:16][C:15](=O)[N:14]([CH3:20])[C:13]1=O.[H][H]>[Pt].C(OCC)(=O)C>[NH2:9][C:5]1[C:6]([F:8])=[CH:7][C:2]([Cl:1])=[C:3]([N:12]2[CH:17]=[N:16][CH2:15][N:14]([CH3:20])[CH2:13]2)[CH:4]=1참가 물질
5
실험 절차
A mixture of 1-(2-chloro-4-fluoro-5-nitrophenyl)-3-methyl-s-triazine-2,4,6(1H,3H,5H)-trione (28.5 g, 0.09 mol) and 5% platinum on activated carbon (1 g) in ethyl acetate is hydrogenated at 55 psi until hydrogen uptake is complete. The reaction mixture is then filtered and concentrated in vacuo to give the title product as a white solid, mp 244°-245° C.
후처리
- filtrationThe reaction mixture is then filtered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-08b8b8866d334d3cae4bec9581c21467
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05726126
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