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Acetic Acid → Tert-butyl (2-{[(5-cyano-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]amino}ethyl)carbamate

HRID 1466023
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HRID 1466023 반응식
[CH:1]([CH:3]1[CH2:12][CH2:11][CH2:10][C:9]2[C:8]([C:13]#[N:14])=[CH:7][CH:6]=[CH:5][C:4]1=2)=O.[C:15]([O:19][C:20](=[O:25])[NH:21][CH2:22][CH2:23][NH2:24])([CH3:18])([CH3:17])[CH3:16].CC(O)=O.[BH3-]C#N.[Na+]>CO.C(Cl)Cl.O>[C:13]([C:8]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:9]=1[CH2:10][CH2:11][CH2:12][CH:3]2[CH2:1][NH:24][CH2:23][CH2:22][NH:21][C:20](=[O:25])[O:19][C:15]([CH3:18])([CH3:16])[CH3:17])#[N:14]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

8

반응물 4

HCID 176Acetic AcidHCID 187201N-BOC-ethylenediamineHCID 5003444Sodium cyanoborohydrideHCID 772306645-Formyl-5,6,7,8-tetrahydronaphthalene-1-carbonitrile

생성물 1

HCID 131732671Tert-butyl (2-{[(5-cyano-1,2,3,4-tetrahydronaphthalen-1-yl)methyl]amino}ethyl)carbamate

시약·촉매·용매 3

HCID 887
Methanol
용매
2회
HCID 962Water용매
HCID 6344Dichloromethane용매

실험 절차

A solution of 5-Formyl-5,6,7,8-tetrahydronaphthalene-1-carbonitrile (0.30 g, 1.6 mmol) in MeOH (8 mL) was added (2-amino-ethyl)-carbamic acid tert-butyl ester (0.26 g, 1.6 mol) in MeOH (8 mL), followed by AcOH (0.29 g, 4.8 mmol) and NaBH3CN (0.20 g, 3.2 mmol). The reaction mixture was stirred 2-3 h, and then water (20 mL) and DCM (20 mL) was added. Extracted with DCM, and the organic layers were dried over anhydrous Na2SO4, evaporate to give the crude product, which was purified by column to give the title compound. MS m/z: 330 [M+1]+.

후처리

  1. extractionExtracted with DCM
  2. dry with materialthe organic layers were dried over anhydrous Na2SO4
  3. customevaporate
  4. customto give the crude product, which
  5. customwas purified by column

출처 및 근거

ORD 기록
ord-31ddb32677ab412cb1c035f020e82260
출처 데이터셋
uspto-grants-2015_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08999990B2

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