Acetic Anhydride → N-(4-Phenoxyphenyl)acetamide

HRID 1466469노트

반응식

HRID 1466469 반응식
[O:1]([C:8]1[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:22](OC(=O)C)(=[O:24])[CH3:23]>ClCCl>[O:1]([C:8]1[CH:9]=[CH:10][C:11]([NH:12][C:22](=[O:24])[CH3:23])=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 8764(4-Aminophenoxy)benzene

생성물 1

HCID 80579N-(4-Phenoxyphenyl)acetamide수율 89.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Commercial available 4-phenoxy-aniline (4.16 g, 20.8 mmol) was dissolved in dichloromethane (100 mL), and triethylamine (3.05 g, 31.1 mmol) and acetic anhydride (2.22 g, 20.8 mmol) were added in drops. The mixture was stirred for 1 h at 0° C. to room temperature. After completion of the reaction, the mixture was filtered using dichloromethane and crystallized to give the title compound (4.50 g, 18.6 mmol)

후처리

  1. customAfter completion of the reaction
  2. filtrationthe mixture was filtered
  3. customcrystallized

출처 및 근거

ORD 기록
ord-137788353f0e4acfaa18cbfa46c1847f
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09000028B2

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