Chloroacetone → HCID 66764943, 화합물

HRID 1466816노트

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HRID 1466816 반응식
[CH2:1]([O:3][C:4](=[O:14])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([SH:13])[CH:6]=1)[CH3:2].C(N(CC)CC)C.Cl[CH2:23][C:24](=[O:26])[CH3:25].CCOC(C)=O>C1COCC1>[CH2:1]([O:3][C:4](=[O:14])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([S:13][CH2:23][C:24](=[O:26])[CH3:25])[CH:6]=1)[CH3:2]

참가 물질

6

반응물 4

HCID 6571ChloroacetoneHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 66764668HCID 66764668, 화합물

생성물 1

HCID 66764943HCID 66764943, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3-Mercapto-4-methoxy-benzoic acid ethyl ester (1.29 g, 6.08 mmol) and triethylamine (2.12 mL, 15.19 mmol) were dissolved in THF (20 mL) at 0° C. Chloroacetone (0.58 mL, 7.29 mmol) was then added and the reaction stirred at room temperature for 30 minutes. It was then allowed to slowly warm to room temperature and stirred an additional 30 minutes. Standard aqueous workup followed by silica gel chromatography (0-70% EtOAc in hexanes) gave the title compound.

후처리

  1. temperatureto slowly warm to room temperature
  2. stirringstirred an additional 30 minutes

출처 및 근거

ORD 기록
ord-3720f8e87e0343edb07455a2d4f8fa81
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09000025B2

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