Cesium carbonate → 1-(cyclopropylmethyl)-4-iodo-1H-pyrazole
반응식
[I:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.Br[CH2:8][CH:9]1[CH2:11][CH2:10]1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[CH:9]1([CH2:8][N:4]2[CH:3]=[C:2]([I:1])[CH:6]=[N:5]2)[CH2:11][CH2:10]1참가 물질
5
실험 절차
4-Iodo-1H-pyrazole (0.50 g, 2.5 mmol), bromomethyl cyclopropane (0.75 mL, 7.5 mmol), and cesium carbonate (1.20 g, 3.75 mmol) were combined in DMF (10 mL) and stirred at room temperature for overnight. The mixture was subjected to standard aqueous workup, and the crude residue was purified on silica gel (0-20% EtOAc in hexanes) to afford the title compound.
후처리
- customthe crude residue was purified on silica gel (0-20% EtOAc in hexanes)
출처 및 근거
- ORD 기록
- ord-b36178626e54437bb3bdb52c3f2f8f65
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09000025B2
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