Potassium Carbonate → HCID 178468952, 화합물

반응식

[CH2:1]([O:3][C:4](=[O:26])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17](Cl)=[CH:18][CH:19]=3)[N:14]([C:23]#[N:24])[C:13]=2[CH3:25])[CH:6]=1)[CH3:2].[ClH:27].[NH2:28][OH:29].C(=O)([O-])[O-].[K+].[K+]>CCO>[CH2:1]([O:3][C:4](=[O:26])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[C:16]([F:22])[C:17]([Cl:27])=[CH:18][CH:19]=3)[N:14]([C:23](=[NH:24])[NH:28][OH:29])[C:13]=2[CH3:25])[CH:6]=1)[CH3:2]

참가 물질

실험 절차

3-(6-Chloro-1-cyano-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester (0.45 g, 1.15 mmol), hydroxylamine hydrochloride (0.40 g, 5.79 mmol), and potassium carbonate (0.80 g, 5.79 mmol) were combined in absolute EtOH (4 mL) and stirred at reflux for overnight. The heterogeneous mixture was then filtered, and the solids were washed with hot absolute EtOH (2×10 mL). The resulting filtrate was concentrated to dryness under reduced pressure to afford the title compound.