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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → Hydrochloric Acid

HRID 1467310
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HRID 1467310 반응식
[C:1]1([N:7]2[CH2:12][CH2:11][CH2:10][C@@H:9]([NH:13]C(=O)OC(C)(C)C)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:21]>CO>[C:1]1([N:7]2[CH2:12][CH2:11][CH2:10][C@@H:9]([NH2:13])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:21]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 70652814(R)-3-(Boc-amino)-1-phenyl-piperidine

생성물 2

HCID 313Hydrochloric AcidHCID 70652306(3R)-1-phenylpiperidin-3-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of tert-butyl [(3R)-1-phenylpiperidin-3-yl]carbamate (133 mg, 0.483 mmol) in 3 M HCl in MeOH (3 ml) was heated to 70° C. for 3 hr. The reaction mixture was concentrated in vacuo to provide crude (3R)-1-phenylpiperidin-3-amine as the bis HCl salt, which was used as-is without further purification.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-14f36128afe04dfba23dc66a4b1e28c8
출처 데이터셋
uspto-grants-2015_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08999957B2

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