Methyl iodide → HCID 86696632, 화합물
반응식
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][C:7](=[O:14])[N:8]2[CH2:11][CH2:12][OH:13])=[C:4]([Cl:15])[N:3]=1.[C:16]([O-])([O-])=O.[K+].[K+].CI>CN(C=O)C>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:16])[C:7](=[O:14])[N:8]2[CH2:11][CH2:12][OH:13])=[C:4]([Cl:15])[N:3]=1참가 물질
5
반응 조건
- 온도
- 27.5 °C
실험 절차
A mixture of 2-amino-6-chloro-9-(2-hydroxyethyl)-7H-purin-8-one obtained in step 2 (13 g, 56.7 mmol), K2CO3 (11.5 g, 84 mmol), methyl iodide (12 g, 85.15 mmol) and DMF (130 ml) were stirred at 25-30° C. for 16 hours. The reaction mixture was concentrated and purified by column chromatography using 60-120 silica gel and 4% methanol in DCM as an eluent to obtain 2-amino-6-chloro-9-(2-hydroxyethyl)-7-methyl-purin-8-one (8 g, 58%) as an off white solid.
후처리
- concentrationThe reaction mixture was concentrated
- custompurified by column chromatography
출처 및 근거
- ORD 기록
- ord-333da6c11582478ea6579a56309b7466
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09006177B2
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