Bromide ion → (4-(Bromomethyl)-2,6-difluorophenyl)(methyl)sulfane

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[F:1][C:2]1[CH:3]=[C:4]([CH2:11]O)[CH:5]=[C:6]([F:10])[C:7]=1[S:8][CH3:9].[Br-:13].FC1C=C(C=C(F)C=1SC)C=O>>[Br:13][CH2:11][C:4]1[CH:5]=[C:6]([F:10])[C:7]([S:8][CH3:9])=[C:2]([F:1])[CH:3]=1

참가 물질

반응물 3

HCID 259Bromide ion

HCID 22746033(3,5-Difluoro-4-(methylthio)phenyl)methanol

HCID 227466823,5-Difluoro-4-(methylthio)benzaldehyde

생성물 1

HCID 22746076(4-(Bromomethyl)-2,6-difluorophenyl)(methyl)sulfane

실험 절차

The product from step B was converted to the bromide according to the procedure from intermediate 5 (step A). 1H NMR (500 MHz, CDCl3) δ 7.36 (d, J 7.5 Hz, 2H), 4.82 (s, 2H), 2.88 (s, 3H)

출처 및 근거

ORD 기록: ord-cb7a942a440047ad92464ae810f12cb4
출처 데이터셋: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09006228B2

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