2,4-Dichloropyrimidine → 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

HRID 14701

반응식

HRID 14701 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[CH:15][CH:16]=1)=[O:10]>>[Cl:1][C:2]1[N:7]=[C:6]([C:15]2[CH:16]=[C:11]([CH:12]=[CH:13][CH:14]=2)[CH:9]=[O:10])[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 775312,4-DichloropyrimidineHCID 27343563-Formylphenylboronic acid

생성물 1

HCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehyde수율 60%

실험 절차

2,4 dichloropyrimidine and 3-formyl phenyl boronic acid were coupled following procedure A. The yield was 60%. LC-MS showed the product was >95% pure and had the expected M+H+ of 219. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 610.1 (s, 1H) 8.7 (d, 1H) 8.6 (m, 1H) 8.4 (m, 1H) 8.1 (m, 1H) 7.7 (m, 2H).

출처 및 근거

ORD 기록
ord-e0e0050b65ba4b42a63f0cab5037d450
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732444B2

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