Potassium Hydroxide → HCID 178426257, 화합물

HRID 1470224노트

반응식

HRID 1470224 반응식
[CH3:1][C:2]1[C:7]2=[N:8][CH:9]=[C:10]([C:13]3[N-:14][N:15]=[N:16][N:17]=3)[C:11](=[O:12])[N:6]2[CH:5]=[CH:4][CH:3]=1.[K+].[OH-].[K+]>O.Cl>[CH3:1][C:2]1[C:7]2=[N:8][CH:9]=[C:10]([C:13]3[NH:14][N:15]=[N:16][N:17]=3)[C:11](=[O:12])[N:6]2[CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 443866Pemirolast potassium

생성물 1

HCID 178426257HCID 178426257, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

실험 절차

Pemirolast free acid was prepared by dissolving pemirolast potassium in water and acidifying to pH 1 with 6M HCl which caused the free acid to precipitate from solution. The crystals formed were filtered, washed with water and dried under vacuum. Pemirolast potassium was in turn prepared analogously to the methodology described in Example 4 (steps Ia and Ib) below, using 2M KOH instead of 2M NaOH, and recrystallising from water:isopropanol in a 1:2, instead of a 2:1, ratio.

후처리

  1. customto precipitate from solution
  2. customThe crystals formed
  3. filtrationwere filtered
  4. washwashed with water
  5. customdried under vacuum
  6. customprepared analogously to the methodology
  7. customrecrystallising from water

출처 및 근거

ORD 기록
ord-be2ce49101144f7ea7005d3cfff820d5
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09006431B2

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