Diazomethane → Methyl 4-bromo-2,3,5,6-tetrafluorobenzoate
반응식
[Br:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[C:5]([C:6]([OH:8])=[O:7])=[C:4]([F:13])[C:3]=1[F:14].[N+](=[CH2:17])=[N-]>CO>[CH3:17][O:7][C:6](=[O:8])[C:5]1[C:4]([F:13])=[C:3]([F:14])[C:2]([Br:1])=[C:10]([F:11])[C:9]=1[F:12]참가 물질
4
실험 절차
To a solution of 4-bromo-2,3,5,6-tetrafluoro-benzoic acid (20 g, 73.49 mmol) in methanol (20 mL) was added an ethereal solution of diazomethane gas until the starting material is completely consumed. Reaction mixture was then evaporated under reduced pressure. The crude solid obtained was purified by flash column chromatography using 5% ethyl acetate in hexane, to obtain title compound as colorless crystalline solid (18 g, 85%).
후처리
- customis completely consumed
- customReaction mixture
- customwas then evaporated under reduced pressure
- customThe crude solid obtained
- customwas purified by flash column chromatography
출처 및 근거
- ORD 기록
- ord-d77135383d1b4b8db240f572ea533946
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09006454B2
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