Diazomethane → Methyl 2-amino-5-chloro-3-nitrobenzoate

HRID 1470622

반응식

HRID 1470622 반응식
[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([Cl:14])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[N+](=[CH2:17])=[N-]>CO>[CH3:17][O:5][C:4](=[O:6])[C:3]1[CH:7]=[C:8]([Cl:14])[CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:2]=1[NH2:1]

참가 물질

4

반응물 2

HCID 9550DiazomethaneHCID 2320552-Amino-5-chloro-3-nitrobenzoic acid

생성물 1

HCID 615489Methyl 2-amino-5-chloro-3-nitrobenzoate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-amino-5-chloro-3-nitro-benzoic acid (2 g, 1.0 mmol) in methanol (100 mL) was added a saturated ethereal solution of diazomethane gas (50 mL) till all the starting material was consumed. The reaction mixture was concentrated to dryness and the residue obtained was purified by column chromatography using 5% ethyl acetate in hexane as an eluent to obtain the title compound as yellow solid which was directly used for the next step (1.8 g, 84.11%).

후처리

  1. customwas consumed
  2. concentrationThe reaction mixture was concentrated to dryness
  3. customthe residue obtained
  4. customwas purified by column chromatography

출처 및 근거

ORD 기록
ord-d06d9bf51a264e35af1a34157235202a
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09006454B2

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