Sodium Hydroxide → 2-Nitro-6-(pyridin-2-yl)aniline

HRID 1472183노트

반응식

HRID 1472183 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[C:5]=1[NH:16]C(=O)C)([O-:3])=[O:2].[OH-].[Na+]>CO>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[C:5]=1[NH2:16])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86701070N-(2-nitro-6-(pyridin-2-yl)phenyl)acetamide

생성물 1

HCID 130010352-Nitro-6-(pyridin-2-yl)aniline수율 65.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of N-(2-nitro-6-(pyridin-2-yl)phenyl)acetamide (XCVIII) (4.41 g, 17 mmol, 1 eq) in MeOH (20 mL) was added 2N NaOH aqueous (50 mL) and the mixture was refluxed until the stirring material was consumed completely. The mixture was concentrated in vacuo to remove the MeOH and the precipitate was collected by filtration to afford 2-nitro-6-(pyridin-2-yl)aniline (XCIX) (2.4 g, 11.2 mmol, 65% yield) as a yellow solid. ESIMS found for C11H9N3O2 m/z 216 (M+H).

후처리

  1. temperaturethe mixture was refluxed until the stirring material
  2. customwas consumed completely
  3. concentrationThe mixture was concentrated in vacuo
  4. customto remove the MeOH
  5. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-be3b608a50ca4bf4b03427ec0112927a
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09012472B2

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