Sodium Hydroxide → Sodium 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate

HRID 1473302노트

반응식

HRID 1473302 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:9]=2[CH:10]=[CH:11][C:12]([S:18]([O:21]CC(F)(F)F)(=[O:20])=[O:19])=[CH:13]3)=[C:4]([O:27][CH3:28])[CH:3]=1.[OH-].[Na+:30]>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:9]=2[CH:10]=[CH:11][C:12]([S:18]([O-:21])(=[O:19])=[O:20])=[CH:13]3)=[C:4]([O:27][CH3:28])[CH:3]=1.[Na+:30]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 866873582,2,2-Trifluoroethyl 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate

생성물 1

HCID 86687359Sodium 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate수율 99.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A round bottomed flask was charged with 2,2,2-trifluoroethyl 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate (1.729 g, 4.01 mmol) and CH2Cl2 (8.03 mL). Sodium hydroxide (2M in MeOH) (4.01 mL, 8.03 mmol) was added at rt. The solution was capped and maintained at rt for 18 h resulting in a white precipitate. The white solid was collected by vacuum filtration, rinsing with diethyl ether to yield sodium 5-(4-chloro-2-methoxyphenyl)naphthalene-2-sulfonate (1.481 g, 3.99 mmol) as a fluffy white solid. The solid was used directly without further purification.

후처리

  1. customThe solution was capped
  2. customresulting in a white precipitate
  3. filtrationThe white solid was collected by vacuum filtration
  4. washrinsing with diethyl ether

출처 및 근거

ORD 기록
ord-d91bc7b42bd946f3b2675a89d9ce6d67
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09012443B2

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