Hydrochloric Acid → 5-Hydroxy-2-Methoxybenzaldehyde
반응식
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:8]([O:11]COC)=[CH:7][C:4]=1[CH:5]=[O:6].Cl>C1COCC1.O>[OH:11][C:8]1[CH:9]=[CH:10][C:3]([O:2][CH3:1])=[C:4]([CH:7]=1)[CH:5]=[O:6]참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
To a solution of 2-methoxy-5-(methoxymethoxy)benzaldehyde (10 g, 0.05 mol) in THF (100 mL) was added 3 N HCl (150 mL). The reaction was stirred at 50° C. for 30 min, cooled to rt, and diluted with water (100 mL). The mixture was neutralized to pH 7-8 and extracted with EtOAc (200 mL) three times. The organic layer was dried over Na2SO4 and concentrated to give 5-hydroxy-2-methoxybenzaldehyde.
후처리
- temperaturecooled to rt
- extractionextracted with EtOAc (200 mL) three times
- dry with materialThe organic layer was dried over Na2SO4
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-adb963c887bc4b059151ee10ff3d9a10
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09018210B2
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