Water → 2-Bromo-2-phenylacetamide

HRID 1473947

반응식

HRID 1473947 반응식
[C:1]1([CH2:7][C:8]([NH2:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:11]N1C(=O)CCC1=O.O>ClCCl>[Br:11][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:8]([NH2:10])=[O:9]

참가 물질

5

반응물 3

HCID 962WaterHCID 7680BenzeneacetamideHCID 67184N-bromobutanimide

생성물 1

HCID 2420282-Bromo-2-phenylacetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Benzeneacetamide (3.0 g, 0.022 mol) was dissolved in dichloromethane (60 mL) and N-bromosuccinimide (4.0 g, 0.022 mol) was added. The reaction was stirred at room temperature under UV light for 24 hr. The mixture was poured into water and the layers were separated. The organic layer was washed with water (2×50 mL) then with brine (1×50 mL). The organic layer was dried (magnesium sulfate) then chromatographed on silica (40% ethyl acetate/hexanes) to give 2-Bromo-2-phenylacetamide, compound h Rf 0.37, 40% ethyl acetate/hexanes; MS m/z 216 (M+H).

후처리

  1. customthe layers were separated
  2. washThe organic layer was washed with water (2×50 mL)
  3. dry with materialThe organic layer was dried (magnesium sulfate)
  4. customthen chromatographed on silica (40% ethyl acetate/hexanes)

출처 및 근거

ORD 기록
ord-9a44fd266a1a49c49143cf9c13602117
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018208B2

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