반응식
[OH-].[Na+].S(O)(O)(=O)=O.[CH3:8][S:9][C:10](=[NH:12])[NH2:11].CC(OC)(C)C.C1COCC1.[NH2:24][C:25]1[C:26]([C:33](OC(C)=CC(=O)NC(C)(C)C)=[O:34])=[N:27][C:28]([Cl:32])=[C:29]([NH2:31])[N:30]=1>O>[NH2:24][C:25]1[C:26]([C:33]([NH:12][C:10]([S:9][CH3:8])=[NH:11])=[O:34])=[N:27][C:28]([Cl:32])=[C:29]([NH2:31])[N:30]=1참가 물질
6
반응물 4
생성물 1
시약·촉매·용매 1
실험 절차
To NaOH (1 mol/l in water; 9.2 mL; 9.2 mmol) is added S-methylisothiourea sulphate (1.78 g; 6.1 mmol. The mixture is stirred until complete solution is achieved. TBME/THF (1:1; 30 mL) and then 1-(tert-butylcarbamoyl)prop-1-en-2-yl 3,5-diamino-6-chloropyrazine-2-carboxylate (Intermediate B.1; 2.00 g; 6.10 mmol) are added and the mixture is stirred at r.t. over night, then water (6 mL) is added. The precipitate formed is filtered off with suction, washed successively with water, methanol and then with diethyl ether and then dried at 50° C. to yield the title compound.
후처리
- stirringthe mixture is stirred at r.t. over night
- customThe precipitate formed
- filtrationis filtered off with suction
- washwashed successively with water, methanol
- dry with materialwith diethyl ether and then dried at 50° C.
출처 및 근거
- ORD 기록
- ord-ab8f4d521b3e4c4fbb509a966ef205ad
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09018215B2
연결된 노트
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