Diisopropylethylamine → 5-bromo-N-(2-(4-fluorophenyl)-2-methylpropyl)pyrimidin-2-amine

HRID 1474089노트

반응식

HRID 1474089 반응식
Cl[C:2]1C=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([CH3:20])([CH3:19])[CH2:17][NH2:18])=[CH:12][CH:11]=1.CC[N:23](C(C)C)C(C)C>C1(C)C=CC=CC=1>[Br:8][C:5]1[CH:4]=[N:3][C:2]([NH:18][CH2:17][C:16]([C:13]2[CH:12]=[CH:11][C:10]([F:9])=[CH:15][CH:14]=2)([CH3:20])[CH3:19])=[N:23][CH:6]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 27344145-Bromo-2-chloropyridineHCID 212510232-(4-Fluorophenyl)-2-methylpropan-1-amine

생성물 1

HCID 674528925-bromo-N-(2-(4-fluorophenyl)-2-methylpropyl)pyrimidin-2-amine수율 40%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
80 °C

실험 절차

To a 20 dram vial was added 2-chloro-5-bromopyridine (440 mg, 2.3 mmol, 1.1 equiv), 2-(4-fluorophenyl)-2-methylpropan-1-amine (350 mg, 2.1 mmol, 1.0 equiv), DIPEA (1.0 mL, 5.7 mmol, 2.7 equiv), and toluene (5 mL). The vial was heated in an oil bath to 80° C. and stirred for 12 h, concentrated, and purified by silica gel column chromatography (0-30% EtOAc/hexanes) to give 270 mg (40%) of 5-bromo-N-(2-(4-fluorophenyl)-2-methylpropyl)pyrimidin-2-amine as a white solid.

후처리

  1. concentrationconcentrated
  2. custompurified by silica gel column chromatography (0-30% EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-7d951fdf4e6a427ba56f1da541a73439
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018223B2

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