Acetic Anhydride → HCID 75238472, 화합물

HRID 1474482

반응식

HRID 1474482 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=O.[CH3:13][O:14][CH2:15][C:16]1[O:20][C:19]([CH:21]=O)=[CH:18][CH:17]=1.C([O-])(=O)C.[Na+].C(OC(=O)C)(=O)C>O>[CH3:13][O:14][CH2:15][C:16]1[O:20][C:19]([CH:21]=[C:9]2[C:10](=[O:11])[O:12][C:6]([C:2]3[S:1][CH:5]=[CH:4][CH:3]=3)=[N:8]2)=[CH:18][CH:17]=1

참가 물질

6

반응물 4

HCID 7918Acetic AnhydrideHCID 747115-(Methoxymethyl)-2-furaldehydeHCID 517045Sodium AcetateHCID 679227((2-Thienylcarbonyl)amino)acetic acid

생성물 1

HCID 75238472HCID 75238472, 화합물수율 50.7%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
90 °C

실험 절차

To a screw-capped test tube, N-(2-thienylcarbonyl)glycine (56 mg, 0.3 mmol), 5-(methoxymethyl)-2-furancarboxaldehyde (46 mg, 0.3 mmol), sodium acetate (25 mg, 0.3 mmol) and acetic anhydride (0.3 mL) were added. The test tube was sealed, and it was then stirred at an external temperature of 90° C. Three hours later, the temperature of the reaction solution was returned to room temperature, and water (1.5 mL) was then added thereto. The obtained mixture was stirred at the same temperature as described above for 1.5 hours. Thereafter, the precipitated crystal was collected by filtration, and it was washed with water (5 mL) and was then dried under reduced pressure, so as to obtain 44 mg of the above-captioned compound.

후처리

  1. customThe test tube was sealed
  2. customThree hours
  3. customwas returned to room temperature
  4. stirringThe obtained mixture was stirred at the same temperature
  5. customas described above for 1.5 hours
  6. filtrationThereafter, the precipitated crystal was collected by filtration, and it
  7. washwas washed with water (5 mL)
  8. customwas then dried under reduced pressure

출처 및 근거

ORD 기록
ord-78969d70748d4b8eb24d18508aa0bfd7
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018238B2

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