4,7-Difluoro-2,3-dihydro-1H-inden-1-amine → HCID 117736897, 화합물

HRID 1474576노트

반응식

HRID 1474576 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[NH2:12].[C:13]([O:17][C:18]([N-:20][S:21](N1C=CC(=[N+](C)C)C=C1)(=[O:23])=[O:22])=[O:19])([CH3:16])([CH3:15])[CH3:14]>C(Cl)Cl.CCOC(C)=O.Cl>[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[NH:12][S:21]([NH:20][C:18](=[O:19])[O:17][C:13]([CH3:15])([CH3:14])[CH3:16])(=[O:22])=[O:23]

참가 물질

6

반응물 2

HCID 584399044,7-Difluoro-2,3-dihydro-1H-inden-1-amineHCID 178482962HCID 178482962, 화합물

생성물 1

HCID 117736897HCID 117736897, 화합물

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 4,7-difluoro-2,3-dihydro-1H-inden-1-amine (CAS No. 625471-13-8, 1.19 g, 11.2 mmol) in DCM (50 mL) were added [(tert-Butoxy)carbonyl]{[4-(dimethyliminio)pyridin-1(4H)-yl]sulfonyl}amide (3.70 g, 12.3 mmol) and TEA (4.66 mL, 33.5 mmol) at room temperature. The resulting solution was stirred for 75 hours at room temperature. The reaction mixture was diluted with AcOEt and 1N HCl and the layers were separated. The organic layer was dried over anhydrous Na2SO4 and evaporated in vacuo to afford the title compound (3.82 g, 11.0 mmol).

후처리

  1. customthe layers were separated
  2. dry with materialThe organic layer was dried over anhydrous Na2SO4
  3. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-9d3a9702ac064e4abd005287323ba8e3
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09018260B2

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