Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloroethanol → 4-(Diphenylmethyl)-1-piperazineethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloroethanol | HCID 34 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Benzhydrylpiperazine | HCID 70048 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-(Diphenylmethyl)-1-piperazineethanol | HCID 4742573 | — |
반응 단계
To a solution of benzhydryl piperazine (7.28 gm) in toluene (35 ml) at room temperature, dimethyl formamide (70 ml), 2-chloroethanol (5 ml) and potassium carbonate (5 gm) were added. The reaction mass was heated to reflux with constant stifling for 14-16 hours. Reaction mass was cooled, filtered, and concentrated under vacuum to get 2-(4-benzhydryl piperazine-1-yl) ethanol (yield: 7.5 gm).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09018376B2 |
| 출처 데이터셋 | uspto-grants-2015_04 |
| ORD ID | ord-b32e4fac03094b549fde94ce447f91f4 |
| 출처 메모 | uspto-grants-2015_04 |