反应详情

To a solution of benzhydryl piperazine (7.28 gm) in toluene (35 ml) at room temperature, dimethyl formamide (70 ml), 2-chloroethanol (5 ml) and potassium carbonate (5 gm) were added. The reaction mass was heated to reflux with constant stifling for 14-16 hours. Reaction mass was cooled, filtered, and concentrated under vacuum to get 2-(4-benzhydryl piperazine-1-yl) ethanol (yield: 7.5 gm).

1. temperatureThe reaction mass was heated
2. temperatureto reflux with constant stifling for 14-16 hours
3. customReaction mass
4. temperaturewas cooled
5. filtrationfiltered
6. concentrationconcentrated under vacuum