Hydrazine hydrate (1:1) → HCID 178452040, 화합물

HRID 1476882노트

반응식

HRID 1476882 반응식
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:25]#[N:26])[N:8]=[C:9]2[O:12][C@H:13]2[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14]2)=[CH:4][CH:3]=1.[NH2:27][NH2:28].O>CO>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:25]([NH:27][NH2:28])=[NH:26])[N:8]=[C:9]2[O:12][C@H:13]2[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:23])([CH3:22])[CH3:24])=[O:19])[CH2:14]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 90387178(S)-tert-butyl 3-((7-chloro-3-cyanoisoquinolin-1-yl)oxy)pyrrolidine-1-carboxylate

생성물 1

HCID 178452040HCID 178452040, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a mixture of (S)-tert-butyl 3-((7-chloro-3-cyanoisoquinolin-1-yl)oxy)pyrrolidine-1-carboxylate (300 mg, 1.61 mmol) in MeOH (4 mL) was added NH2NH2.H2O (5 mL). The resulting mixture was heated to reflux for 2 hours. The solvents were removed in vacuo to give the title compound, which was used without further purification. ESI-MS m/z [M+H]+ 406.1.

후처리

  1. temperatureThe resulting mixture was heated
  2. temperatureto reflux for 2 hours
  3. customThe solvents were removed in vacuo

출처 및 근거

ORD 기록
ord-34cece10a5c849d39e17861fa81f241e
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09402841B2

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