Methyl iodide → HCID 23023145, 화합물

HRID 1477394노트

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HRID 1477394 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH3:10])[CH:3]=1.[Li+].[CH3:12]C([N-]C(C)C)C.CI>C1COCC1>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH2:10][CH3:12])[CH:3]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 1442674-Bromo-2-methylbenzonitrileHCID 2724682Lithium diisopropylamide

생성물 1

HCID 23023145HCID 23023145, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-bromo-2-methylbenzonitrile (0.4 g, 2.0 mmol) in dry THF (10 mL) was slowly added LDA (1.3 mL, 1.8 M in THF) at 78° C. and stirred at this temperature for additional 30 min. Methyl iodide (0.15 mL, 2.4 mmol) was added) at 78° C. to the above dark purple solution and the mixture was warmed to room temperature over 3 h. The reaction was quenched with water, extracted with ether, which was then was washed with brine, dried and concentrated. 4-Bromo-2-ethylbenzonitrile (0.34 g) was purified by Combiflash.

후처리

  1. customat 78° C.
  2. customThe reaction was quenched with water
  3. extractionextracted with ether, which
  4. washwas then was washed with brine
  5. customdried
  6. concentrationconcentrated
  7. custom4-Bromo-2-ethylbenzonitrile (0.34 g) was purified by Combiflash

출처 및 근거

ORD 기록
ord-3bbdb0ef7502494bbd3f975ca6a9a75b
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403775B2

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