Methyl iodide → 6-Bromo-1-methyl-1H-indazole

HRID 1477398

반응식

HRID 1477398 반응식
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][CH:3]=1.[OH-].[K+].[CH3:13]I>CO.C(OCC)C>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH3:13])=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 178424716-Bromo-1H-indazole

생성물 1

HCID 225586756-Bromo-1-methyl-1H-indazole

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

6-Bromoindazole (400 mg) was dissolved in methanol (10 mL). To this solution, potassium hydroxide (450 mg) was added followed by methyl iodide (0.50 mL) and the mixture was refluxed for 2.5 h. The reaction was cooled, diluted with diethyl ether, washed with water, brine, dried and concentrated. The product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash.

후처리

  1. temperaturethe mixture was refluxed for 2.5 h
  2. temperatureThe reaction was cooled
  3. washwashed with water, brine
  4. customdried
  5. concentrationconcentrated
  6. customThe product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash

출처 및 근거

ORD 기록
ord-fd60054119ac4c63ba66d7cd4b6ce49d
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403775B2

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