N-bromobutanimide → 1-(4-Amino-3-bromo-phenyl)-cyclopropanecarbonitrile
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.C1C(=O)N([Br:20])C(=O)C1>CC#N.CCOC(C)=O>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:11]#[N:12])[CH2:9][CH2:10]2)=[CH:6][C:7]=1[Br:20]참가 물질
5
실험 절차
To a solution of 1-(4-amino-phenyl)-cyclopropanecarbonitrile (96 mg, 0.60 mmol) in MeCN (3 mL) at 0° C. was added NBS (108 mg, 0.60 mmol) and the reaction was allowed to stir overnight. The reaction was diluted with EtOAc (25 mL) and was then washed with saturated aqueous NaHCO3 (1×25 mL). The organic layer was dried (Na2SO4) and concentrated in vacuo to give 114 mg (80%) of 1-(4-amino-3-bromo-phenyl)-cyclopropanecarbonitrile. The crude product was used without further purification.
후처리
- washwas then washed with saturated aqueous NaHCO3 (1×25 mL)
- dry with materialThe organic layer was dried (Na2SO4)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-55e16492505e4c3c98431b9fc0e297aa
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09403804B2
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