HCID 86688408, 화합물 → HCID 86688407, 화합물
반응식
[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH:13]C(=O)C2C=CC=CC=2)=[S:12])[N:7]([CH2:22][CH3:23])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]>[OH-].[Na+]>[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH2:13])=[S:12])[N:7]([CH2:22][CH3:23])[N:6]=1)([CH3:4])([CH3:2])[CH3:3]참가 물질
3
반응 조건
- 온도
- 90 °C
실험 절차
A suspension of compound 24 (5 g, 15.1 mmol) in 30 mL of 5% NaOH aqueous solution was stirred in an oil bath of 90° C. for 8 hrs and cooled down to room temperature. Ice was added while stirring to the reaction mixture. The resulting suspension was filtered, and the cake was washed with cold water (10 mL×3) and further dried in vacuo to afford the desired product 8 as an off-white powder.
후처리
- temperaturecooled down to room temperature
- additionIce was added
- stirringwhile stirring to the reaction mixture
- filtrationThe resulting suspension was filtered
- washthe cake was washed with cold water (10 mL×3)
- customfurther dried in vacuo
출처 및 근거
- ORD 기록
- ord-5d1cc4a3486b489aabbd729ff583c6fd
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09403815B2
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