Sodium Hydroxide → HCID 178515324, 화합물

HRID 1478506

반응식

HRID 1478506 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:12][C:13]([F:24])([F:23])[C:14](=O)[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.CS(O)(=O)=O.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.[OH-].[Na+].[NH4+].[OH-]>C(Cl)Cl>[I:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[C:14]([C:13]([F:23])([F:24])[F:12])[C:15]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[C:4]2[OH:6]

참가 물질

7

반응물 5

HCID 14798Sodium HydroxideHCID 14923Ammonium HydroxideHCID 72911Benzoic acid, 2-amino-5-iodo-HCID 2229581,1,1-Trifluoro-3-phenyl-2-propanone2회HCID 86584057Phosphorus Pentoxide-Methanesulfonic Acid

생성물 1

HCID 178515324HCID 178515324, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2-amino-5-iodobenzoic acid (5.20 g, 19.8 mmol), 1,1,1-trifluoro-3-phenylpropan-2-one (3.95 g, 21.0 mmol), and Eaton's reagent (12 mL) in a sealed tube was heated at 100° C. for 2 hours. More 1,1,1-trifluoro-3-phenylpropan-2-one (1.60 g, 8.50 mmol) was added and the mixture was heated for another 2 hours. The reaction was then cooled to room temperature, ice water was added, and the mixture was stirred vigorously for about 20 minutes. 50% Aqueous NaOH and concentrated NH4OH solutions were added until pH 9. The resulting dark brown gummy material that formed was diluted with DCM which resulted in a solid precipitate that was collected by filtration. The solids were washed with water and Et2O and air dried to provide the title compound.

후처리

  1. temperaturethe mixture was heated for another 2 hours
  2. temperatureThe reaction was then cooled to room temperature
  3. customThe resulting dark brown gummy material that formed
  4. customresulted in a solid precipitate that
  5. filtrationwas collected by filtration
  6. washThe solids were washed with water and Et2O and air
  7. customdried

출처 및 근거

ORD 기록
ord-ee02903722fc45adb3f622fc5b987687
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09403816B2

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