Phosphoric Acid → (4R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid

HRID 1479227노트

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HRID 1479227 반응식
[CH3:1][C:2]1([CH3:10])[O:6][C@@H:5]([C:7]([O-:9])=[O:8])[CH2:4][O:3]1.[Na+].OP(O)(O)=O.[Na+].[Cl-]>O.C(OCC)(=O)C>[CH3:1][C:2]1([CH3:10])[O:6][C@@H:5]([C:7]([OH:9])=[O:8])[CH2:4][O:3]1

참가 물질

6

반응물 3

HCID 1004Phosphoric AcidHCID 5234Sodium ChlorideHCID 23717304Sodium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

생성물 1

HCID 10855606(4R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

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온도
0 °C

실험 절차

Sodium (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (1.03 g, 6.1 mmol) was dissolved in a mixture of water (1.2 ml) and ethyl acetate (1.2 ml) and cooled to 0° C. 2 M aqueous H3PO4 solution (7 ml) was added until the reaction mixture reached pH 2. After that the reaction mixture was saturated with NaCl and the reaction mixture was extracted with ethyl acetate (3×20 ml). The organic layer was dried over Na2SO4 and the solvent was removed under reduced pressure. The product (0.73 g, 4.9 mmol, 81%) was used in the next step without any further purification.

후처리

  1. extractionthe reaction mixture was extracted with ethyl acetate (3×20 ml)
  2. dry with materialThe organic layer was dried over Na2SO4
  3. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-55fa3876de5c42608ba05c7a2537af43
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09408919B2

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