Oxygen → Qing Hau Sau

HRID 1479331

반응식

HRID 1479331 반응식
[CH3:1][C@H:2]1[C@@H:7]2[CH2:8][CH2:9][C:10]([CH3:12])=[CH:11][C@@H:6]2[C@H:5]([C@H:13]([C:15]([OH:17])=[O:16])[CH3:14])[CH2:4][CH2:3]1.C1C=CC(C2C3NC(C(C4C=CC=CC=4)=C4C=CC(=C(C5C=CC=CC=5)C5C=CC(=C(C6C=CC=CC=6)C6C=CC=2N=6)N=5)N4)=CC=3)=CC=1.[O:66]=[O:67].FC(F)(F)C(O)=[O:71]>C1(C)C=CC=CC=1>[CH3:1][C@H:2]1[C@@H:7]2[CH2:8][CH2:9][C@:10]3([CH3:12])[O:66][O:67][C@:6]42[C@H:5]([C@@H:13]([CH3:14])[C:15]([O:17][C@@H:11]4[O:71]3)=[O:16])[CH2:4][CH2:3]1

참가 물질

6

반응물 4

HCID 977OxygenHCID 6422Trifluoroacetic acid2회HCID 701865,10,15,20-Tetraphenyl-21,22-dihydroporphyrinHCID 11020893Dihydroartemisinic acid

생성물 1

HCID 9838675Qing Hau Sau수율 62%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

The feed was a solution of dihydroartemisinic acid at a concentration of 0.5 mol/L and the photosensitizer tetraphenylporphyrin at a concentration of 1 mmol/L in toluene (2.95 g dihydroartemisinic acid and 15 mg tetraphenylporphyrin, total volume 25 mL, volumetric flask). The feed was introduced at a flow rate of 1.25 mL/min and the oxygen flow adjusted to 5 mL/min. The solution of trifluoroacetic acid injected into the output stream of the photochemical reactor contains 1.93 mL trifluoroacetic acid filled up to 20 ml with toluene (1.25 M, volumetric flask). The output stream showed a conversion of 89% yielding 62% of the desired artemisinin with a selectivity of 70% (NMR of crude).

후처리

  1. additionThe feed was introduced at a flow rate of 1.25 mL/min

출처 및 근거

ORD 기록
ord-1f7afc127c4e4e5dae608cb054b1e88a
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409142B2

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