Methyl iodide → 3-Bromo-6-methoxypicolinonitrile
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5](=[O:8])[NH:4][C:3]=1[C:9]#[N:10].I[CH3:12]>C1(C)C=CC=CC=1.C(=O)([O-])[O-].[Ag+2]>[Br:1][C:2]1[C:3]([C:9]#[N:10])=[N:4][C:5]([O:8][CH3:12])=[CH:6][CH:7]=1참가 물질
5
실험 절차
A solution of 3-bromo-6-oxo-1,6-dihydropyridine-2-carbonitrile (from Example 15/Step 2) (1.0 eq.), silver carbonate (1.3 eq.), and iodomethane (1.2 eq.) in toluene (0.2 M) was stirred in the dark at room temperature overnight. The solvent was concentrated en vacuo, and the resulting residue was purified by a COMBIFLASH® system (ISCO) using 0-80% ethyl acetate in hexane to give 3-bromo-6-methoxypicolinonitrile.
후처리
- customdark at room temperature
- customovernight
- concentrationThe solvent was concentrated en vacuo
- customthe resulting residue was purified by a COMBIFLASH® system (ISCO)
출처 및 근거
- ORD 기록
- ord-e3e696424e214f24b0cf2023ebf5f8aa
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09408907B2
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