(2R)-2-aminopentan-1-ol → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-butyl)-amide

HRID 1480055노트

반응식

HRID 1480055 반응식
[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][C@H:17]([CH2:20][CH2:21][CH3:22])[CH2:18][OH:19]>>[OH:19][CH2:18][C@H:17]([NH:16][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])[CH2:20][CH2:21][CH3:22]

참가 물질

3

반응물 2

HCID 5324727(2R)-2-aminopentan-1-olHCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

생성물 1

HCID 762824825-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-butyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 12d, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and (2R)-2-amino-1-pentanol (CAN 80696-30-6) as starting materials and isolated (72 mg, 77%) as colorless oil; LC-MS (UV peak area, m/z) 100%, 313.1311 (MH+).

후처리

  1. customisolated (72 mg, 77%) as colorless oil

출처 및 근거

ORD 기록
ord-325944a6410548b58c27b1cec11fdab0
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409866B2

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