2-Amino-3-cyclopropyl-2-methyl-propionitrile → N-(2-cyano-1-cyclopropylpropan-2-yl)-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamide

HRID 1480214

반응식

HRID 1480214 반응식
[F:1][C:2]1([C:6]2[C:7]([O:15][C@@H:16]([CH3:21])[C:17]([F:20])([F:19])[F:18])=[CH:8][C:9]([C:12]([OH:14])=O)=[N:10][CH:11]=2)[CH2:5][O:4][CH2:3]1.[NH2:22][C:23]([CH3:30])([CH2:26][CH:27]1[CH2:29][CH2:28]1)[C:24]#[N:25]>>[C:24]([C:23]([NH:22][C:12]([C:9]1[CH:8]=[C:7]([O:15][C@@H:16]([CH3:21])[C:17]([F:19])([F:18])[F:20])[C:6]([C:2]2([F:1])[CH2:3][O:4][CH2:5]2)=[CH:11][N:10]=1)=[O:14])([CH3:30])[CH2:26][CH:27]1[CH2:29][CH2:28]1)#[N:25]

참가 물질

3

반응물 2

HCID 847160492-Amino-3-cyclopropyl-2-methyl-propionitrileHCID 902149505-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid

생성물 1

HCID 90203420N-(2-cyano-1-cyclopropylpropan-2-yl)-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamide

실험 절차

The title compound was synthesized in analogy to Example 112e, using 5-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid (Example 142b) and 2-Amino-3-cyclopropyl-2-methyl-propionitrile (example 66a) as starting materials and isolated (27.5 mg, 26%); MS (ESI, m/z): 416.5 (M+H+).

후처리

  1. customisolated (27.5 mg, 26%)

출처 및 근거

ORD 기록
ord-744141fe08314e8fa65c0944c018bb43
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409866B2

연결된 노트

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